Paper Key : IRJ************898
Author: Varda Bhanudas Kurhe,Ms.madhuri B.nagare
Date Published: 07 Nov 2024
Abstract
Bacoside A, a bioactive compound from Bacopa monnieri, shows potential in treating Parkinson's disease. However, it's poor solubility and bioavailability limit it's therapeutic efficacy. To develop and optimize a self-nano Emulsifying Drug Delivery System (SNEDDS) for enhancing solubility and bioavailability of Bacoside A. The drug's solubility was evaluated using a saturation solubility study in a variety of oils, including synthetic and edible oils, surfactants, and co-surfactants. To determine the proper concentration ranges for the componentsoil, surfactant, and co-surfactanta pseudo-ternary phase diagram was employed. Oil, surfactant, and co-surfactant were determined to be oleic acid, tween 20, and ethanol based on the results of the saturation solubility study and phase diagram. Based on the drug's solubility and dilution potential, the formulation was optimized using the D-Optimal mixture design. The optimized SNEDDS formulation demonstrated 89% drug release in the in vitro dissolution testing, while the untreated drug extract only released 24% of the medication in 60 minutes. In comparison to pure extract, an ex vivo diffusion investigation revealed that over 90% of the drug diffused from the enhanced SNEDDS formulation. The design of experimentation technique was used to produce the SNEDDS formulation, which showed tremendous promise as a potential replacement for conventional oral formulations of poorly soluble Bacoside A in order to increase solubility and bioavailability.Keywords : Bacoside A, ,Self-Nano Emulsifying Drug Delivery System (SNEDDS), Parkinsons Disease , Solubility Enhancement, Bioavailability Improvement