Paper Key : IRJ************428
Author: Swanand Sambhaji Dupade,Ms.v.p.chopade
Date Published: 19 Nov 2024
Abstract
Nanosuspensions have emerged as an innovative drug delivery system, particularly for enhancing the bioavailability of poorly water-soluble drugs. Composed of nanoparticles dispersed in a liquid medium, nanosuspensions improve dissolution rates and drug absorption by increasing surface area. This review focuses on the key aspects of nanosuspension formulation, including preparation methods, stability factors, and applications across various routes of administration.Nanosuspensions can be prepared using top-down techniques like media milling and high-pressure homogenization, which reduce drug particle size mechanically, or bottom-up methods such as nanoprecipitation, which rely on controlled drug precipitation. Stability is a critical factor, influenced by particle size, zeta potential, and surfactant choice. Stabilizers, including surfactants and polymers, help prevent particle aggregation and improve the suspensions long-term stability.Nanosuspensions have demonstrated great versatility in drug delivery, offering improved bioavailability for oral administration and targeted, controlled release for parenteral, ocular, and pulmonary routes. They are particularly beneficial for hydrophobic drugs, enhancing solubility in the gastrointestinal tract or ensuring localized delivery for ocular and pulmonary treatments.Emerging trends include co-delivery systems and surface-modified nanosuspensions for enhanced targeting, offering potential in cancer therapy and other treatments. While challenges remain in large-scale production and long-term stability, future advancements in particle engineering and solidification techniques hold promise for improving reproducibility and scalability, facilitating their clinical application.In conclusion, nanosuspensions offer a promising platform for overcoming the limitations of traditional drug delivery systems, providing significant improvements in drug solubility, bioavailability, and therapeutic efficacy.