Paper Key : IRJ************741
Author: Pathlavath Rashitha,G. Hari Kiriti Varma
Date Published: 05 Nov 2024
Abstract
The development of oral sustained or controlled release dosage form of Cisplatin has been an interested topic of research for a long period of time. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatment of headache, arthritis, numerous sustained and controlled release formulations of Cisplatin have been made and reported. Cisplatin microsphere were prepared with a coat consisting of alginate and polymer such as Xanthum gum and Sodium alginate by Ionic cross linking technique using CaCl2. The microspheres were evaluated with respect to the yield, particle size, incorporation efficiency, in vitro drug release and stability. Microspheres were characterized by FTIR studies. It was found that the particle size and incorporation efficiency of microspheres increases with increasing drug-to-polymer ratio.