Paper Key : IRJ************879
Author: Joshi Poonam,Dr. R.s. Tomar
Date Published: 04 Jan 2025
Abstract
Bisphenol A (BPA) is a widely recognized endocrine-disrupting chemical found in numerous everyday products, including food containers, medical devices, and consumer goods. Despite its low concentrations in food, chronic exposure to BPA has been linked to a variety of adverse health effects, particularly on liver function and metabolic regulation. BPAs estrogenic, antiandrogenic, and oxidative properties interfere with hormone signaling, leading to disruptions in glucose homeostasis, insulin resistance, and lipid metabolism. The liver, a key organ in detoxification and metabolic regulation, is particularly vulnerable to BPA-induced toxicity. BPA exacerbates oxidative stress, inflammation, and mitochondrial dysfunction, contributing to conditions such as glucose intolerance, hyperinsulinemia, and hepatic inflammation. These effects are further compounded by the potential bioaccumulation of BPA and its ability to interfere with key cellular pathways regulating glucose and lipid metabolism. Moreover, concerns over BPA substitutes, such as bisphenol S (BPS) and bisphenol F (BPF), highlight the need for careful evaluation of their safety and endocrine-disrupting potential. This review underscores the pressing need for continued research into the long-term effects of BPA exposure and the development of safer alternatives to mitigate its health risks.