Paper Key : IRJ************719
Author: Atole Smita Mininath ,Ulka Mote
Date Published: 01 Nov 2024
Abstract
Many benefits, including avoiding hepatic first-pass metabolism, maintaining a constant plasma concentration, safety, and compliance over oral or parenteral pathways, come with drug delivery via the skin. The largest obstacle to transdermal delivery, however, is the fact that only a small number of strong medications with optimal physicochemical characteristics can pass through skin barriers, intracellularly penetrate, and attain therapeutic concentration through this mechanism. Considerable work has gone into creating strategies to improve the drugs transdermal penetration. One of the macroscale physical enhancement techniques that significantly broadens the range of medications available for transdermal and intradermal administration is the use of microneedle. Microneedles typically range in length from 0.1 to 1 mm.. This review covers the components, manufacturing processes, characterization methods, and transdermal delivery applications of microneedle are discussed.One can create solid, coated, hollow, or dissolvable micro needles using a range of materials, including silicon, stainless steel, and polymers. There has been much discussion about their implications for transdermal drug delivery. Ongoing delivery, effectiveness, affordable fabrication, and large-scale manufacturing are still problems, though. This review covers the various characterization techniques as well as the gaps in microneedle manufacturing technology. Additionally covered in this review are their possible effects on applications related to cosmetics, disease diagnostics, drug delivery, and vaccine delivery.