Paper Key : IRJ************018
Author: Chirag Rajendra Hiray
Date Published: 05 Apr 2024
Abstract
ABSTRACT:Migraine, a prevalent neurological condition associated with vascular deviations, is a prominent cause of disability worldwide. Patients are increasingly interested in herbal and alternative therapies as a way of reducing the unpleasant adverse reactions of medication. Zingiber officinale, at times known as ginger, is known for its analgesic properties in a variety of illnesses such headaches, migraines, muscle tension, stomach spasms, and dysmenorrhea. Ginger's broad pharmacological activities make it an excellent option for treating and preventing migraines. The intention of this review is to evaluate ginger's effectiveness and safety in this context. Ginger's bioactive elements has the potential to be an efficient and secure method to treat acute migraine symptoms. As a result, in order to ensure improved absorption rates and pharmacological actions, it is advised to investigate the production of multiple medicinal dosage forms of ginger extract for application globally.KEYWORDS: Ginger Gel, Carbopol, Antimigrain Activity, Gel Formulation.INTRODUCTION MigraineWhat is migraine?Migraine is a neurological illness marked by constant episodes of intense, vibrating pain, generally confined to one side of the head. This pain activates the blood vessel walls in the brain that pass through the meninges, the layers of tissue that surround the brain and spinal cord.TYPES OF MIGRAINE: Aura-associated migraine Aura-free migraine. Chronic migraine. Migraine with paralysis. Migraine caused by menstrual.SYMPTOMS OF MIGRAINE:Headache that vibrates and beats.Sensitivity to both light and sound.Difficulty focusing or concentrating.Discomfort in the abdominal.Nausea.Vomiting.Stiffness or pain in the neck and shoulders are a few of the symptoms of migraine exhaustion. 1,7PHASES OF MIGRAINE: There are four stages to a migraine attack, and they can all appear at the same time:1. Prodrome: Symptoms that precede the actual onset of a migraine can appear up to a day in advance. These could involve changes in mood (such as happiness or depression), excessive blinking, retention of water, increased urination, or food cravings.2. Aura: An aura may appear just before or during an attack of migraines. Some persons might experience sensory disturbances like muscular weakness or a feeling of being took or taken away or visual problems like heat waves or flashing lights. 3.Headache: A migraine's headache phase may or may not be seen. It typically starts out of carefully and become deeper over time.4. Postdrome: The "migraine hangover," or afterwards, is a condition following the headache phase. This phase may be defined as weakness, drowsiness difficulty concentrating, fluctuations in mood, and a general feeling of malaise.MEDICATIONS USED TO TREAT MIGRAINE HEADACHES: 1.The method that triptan drugs operate is by increasing the brain's concentration of the neurotransmitter serotonin. Serotonin decreases blood vessel flexibility and feelings of pain in the brain. 2.Ibuprofen, aspirin, or acetaminophen were a few instances of over-the-counter analgesics that help relieve mild to moderate migraine headaches. 3.Acetaminophen, caffeine, andor a narcotic are only some of the medications used in combination analgesics. For migraines that are insensitive to traditional analgesics, medications work excellently. 4.NSAIDs, or nonsteroidal anti-inflammatory drugs, reduce migraine-related pain and inflammation 1,6