Paper Key : IRJ************918
Author: Zumera Khan ,M.h.dehgan
Date Published: 27 Oct 2023
Abstract
Poorly water-soluble drugs pose a great challenge in drug formation development. The low saturated solubility and dissolution velocity lead to poor bioavailability. For this reason, nanocrystals have attracted a lot of attention. They exhibit advantages like saturation solubility and dissolution velocity. The aim of the study is related to developing and evaluating cyclizine hydrochloride nanocrystals for intranasal drug delivery. Nanocrystals have been prepared by high-pressure homogenization and freeze-drying using lecithin,tween-80, and polyvinyl alcohol. A total of five formulations containing polyvinyl alcohol showed an increase in solubility as compared to other formulations. Studies such as solubility testing, X-ray powder diffractometry, particle size analysis, scanning electron microscopy, drug-polymer interaction, mucoadhesive testing, in-vitro diffusion study, and permeation tests have been done. Nanocrystals increase solubility, thereby increasing bioavailability. An oral dose of cyclizine hydrochloride shows low bio availability due to first-pass metabolism which is also impaired due to gastrointestinal disturbances. The nasal formulation has been prepared in order to pass hepatic metabolism and can be given easily at the of emesis.
DOI LINK : 10.56726/IRJMETS45536 https://www.doi.org/10.56726/IRJMETS45536