Paper Key : IRJ************719
Author: Shaikh Awais Danish Mazhar Jamal,Pathan Ziyauddin Liyakat Khan,Shaikh Saim Raees
Date Published: 17 Nov 2023
Abstract
The objective of the review paper is to discuss the biology and chemistry of oxazolidinone, a novel class of synthetic antibiotics now being used in medicine. Five-membered heterocyclic ring oxazolidinone has a variety of biological uses in medicinal chemistry. In terms of drug discovery, 2-oxazolidinone is the most studied compound. Delpazolid, a brand-new oxazolidinone, was created which is used for the treatment of Tuberculosis. Delpazolid's safety, tolerability, and pharmacokinetics have been assessed in a phase 1 clinical research, which found that, even after three weeks of repeated treatment, it did not produce adverse effects like myelosuppression. Delpazolid shows better activity with lesser adverse effect than previous available drug for the treatment of TB. Delpazolid exhibits in vitro action against Mycobacterium TB and other Gram-positive bacteria. In patients with pulmonary tuberculosis (TB), this study assessed the bactericidal efficacy, safety, and pharmacokinetics of delpazolid.
DOI LINK : 10.56726/IRJMETS45424 https://www.doi.org/10.56726/IRJMETS45424