Paper Key : IRJ************964
Author: Priti Baban Rathod,Rajashri Hiraman Shinde,Sakshi Dnyandev Tagad,Arti Machhindra Tanpure,Pratiksha Ravindra Zagade,Poonam Dattatray Dighe
Date Published: 02 Apr 2025
Abstract
Stroke is a leading cause of long-term disability, often resulting in significant neurological impairments due to damage in the brain's structure and function. Neuroprotective agents offer a promising avenue for mitigating the effects of stroke, promoting brain recovery, and improving patient outcomes. This study investigates novel compounds with potential neuroprotective properties, focusing on their ability to enhance neuroplasticity, reduce neuronal death, and support brain tissue regeneration post-stroke. Through a comprehensive review of recent preclinical and clinical studies, we explore various classes of neuroprotective agents, including small molecules, peptides, and natural compounds, examining their mechanisms of action and therapeutic potential. Additionally, we assess the challenges and limitations of current treatments, emphasizing the need for targeted therapies that can improve recovery outcomes and minimize long-term disability. The findings highlight the importance of early intervention, the potential for combination therapies, and the exciting prospects of gene-based and regenerative medicine in stroke rehabilitation. Ultimately, this research aims to identify novel, effective neuroprotective agents that can be incorporated into clinical stroke therapy to optimize brain recovery and functional restoration. Stroke remains a major global health concern, contributing significantly to mortality and long-term disability due to its devastating effects on brain function. Following a stroke, brain cells undergo ischemic damage, leading to neuronal death, inflammation, and impairment of neuroplasticity, which hinders recovery. Neuroprotective agents have emerged as a promising therapeutic strategy for mitigating post-stroke brain damage, supporting neuronal survival, and promoting functional recovery. This study explores the potential of novel compounds as neuroprotective agents, focusing on their ability to prevent neuronal damage, enhance brain repair mechanisms, and restore cognitive and motor functions in stroke patients. The investigation covers a range of therapeutic approaches, including small molecules, biologics, stem cell-based therapies, and natural products, which exhibit neuroprotective properties through mechanisms such as antioxidative stress, anti-inflammatory effects, modulation of excitotoxicity, and promotion of neurogenesis. Moreover, the study examines recent advances in drug delivery systems, including nanotechnology and gene therapy, to improve the efficacy and targeting of neuroprotective agents. Keywords: Neuroprotective agents, stroke therapy, brain recovery, neuroplasticity, neuronal survival, ischemic damage, small molecules, stem cells, drug delivery systems, antioxidative stress, rehabilitation, gene therapy, functional recovery, etc.