Paper Key : IRJ************925
Author: Puri Hrishikesh Kiran,Tale Sakshi Suresh ,Nawgaje Gopika Dinesh
Date Published: 11 Jul 2024
Abstract
This study investigates the impact of different binder types on the formulation and quality of paracetamol tablets. Paracetamol, a widely used analgesic, is commonly formulated as a tablet. Binder selection significantly influences tablet properties like disintegration time, hardness, and friability, ultimately affecting drug release and patient outcomes. This research involved formulating paracetamol tablets using various binders like starch, PVP, and HPMC. Each formulation was evaluated for its physical properties (e.g., disintegration time, hardness, friability) and drug release characteristics. The data was then analyzed to compare the performance of each binder and identify the most effective option.The study highlights the influence of binder choice on tablet quality, demonstrating that each binder impacts the formulation differently. Findings suggest that Insert specific findings from the study, e.g., starch yielded the fastest disintegration time, PVP led to the highest tablet hardness, HPMC provided the most sustained drug release This information can be valuable for pharmaceutical manufacturers and researchers seeking to optimize paracetamol tablet formulations for improved patient outcomes and enhanced drug delivery. The study concludes with recommendations for future research directions, including exploring the impact of binder concentration and the development of novel binder systems for enhanced tablet properties.
DOI Requested