Paper Key : IRJ************271
Author: Mahevish Samir Ahmad Hudewale,Muskan Mainoddin Mulla
Date Published: 11 Jul 2024
Abstract
Drug delivery is the most preferred route due to its convenience, patient compliance, and formulation flexibility. However, conventional oral dosage forms face challenges like low bioavailability and rapid gastric emptying, leading to frequent dosing. Modern technology has advanced the study and creation of controlled release oral medication delivery systems to address a number of physiological challenges, including variations in stomach retention and emptying time. Because conventional oral dosage forms exit the stomach quickly and locally acting medications quickly empty the stomach, they have low bioavailability, particularly for pharmaceuticals that are less soluble at alkaline pH of the intestine. Therefore, in these situations, the frequency of dose administration is raised. Numerous obstacles face the gastro-retentive drug delivery system, however they can be solved by the recently developed raft-forming technology. The current study demonstrates advancements in this raft forming technique and offers useful information. A summary of the various smart polymer types utilized in their formulation has also been provided. The review focuses on the raft forming system's mechanism, formulation, development, and system optimization elements. It also highlights and discusses parameters that could cause response differences under different physiological settings.
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