Paper Key : IRJ************593
Author: Ms.roshani Vasant Patel ,Dr.rahul Batusing Lovhare,Dr.sunil Pandit Pawar
Date Published: 03 Jan 2025
Abstract
ABSTRACTWhen creating a dosage form, excipients are crucial. Scientists studying drug formulation have realized in recent years that single component excipients don't always perform well enough to enable the proper formulation or manufacturing of specific active pharmaceutical ingredients. Moreover, creating new chemical excipients with better qualities comes at a hefty price. New combinations of current excipients are an intriguing possibility for enhancing excipient functioning these days, given the volume of combination excipients that excipient makers have brought to the commercial market. Through subparticle alterations, particle engineering of individual excipients and excipient combinations through coprocessing has offered an alluring tool for creating high functionality excipients that are appropriate for contemporary tablet manufacturing procedures. Excipients that are coprocessed are a mixture of two or more excipients intended to combine physically without undergoing substantial chemical change, these Compared to individual excipients, coprocessed excipients offer higher functionalities, such as improved flow properties, compressibility, and decreased lubricant sensitivity. All of the developed coprocessed excipients are listed, emphasizing their many useful and multifunctional qualities. Additionally covered are regulatory concerns pertaining to the creation of novel excipients and coprocessed excipients. These excipients include the following: granulationagglomeration process, solvent evaporation, speronization, melt extrusion, flow ability, and compressibility. promoted. Products like Ludipress, Celactose, and Prosolv, among others, have previously demonstrated their value in the market by lowering the product's cost and the amount of excipients while preserving the formulation's effectiveness. However, these excipients have certain drawbacks because of their quality evaluation and reproducibility of the result.KEYWORDS: Excipients , Method of excipient , Novel Excipients, API.
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