Paper Key : IRJ************719
Author: Kanti Lal,Dr. R.s. Tomar,Km Deepshikha
Date Published: 31 Oct 2023
Abstract
Tissue regeneration and repair are comprised of a series of molecular and cellular activities that follow the commencement of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that result from the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that arise following injury play a role in the development of tissue edema. The proliferative stage contracts myofibroblasts and causes fibroplasia in an effort to lessen the region of tissue injury. At this stage, angiogenesis and re-epithelialization processes can still be seen. Endothelial cells can differentiate into mesenchymal components, and this difference appears to be orchestrated by a set of signaling proteins that have been studied in the literature, known as the Hedgehog pathway. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.Keywords: Edema, Myofibroblasts, Proliferation, Angiogenesis, Hedgehog pathway.
DOI LINK : 10.56726/IRJMETS45714 https://www.doi.org/10.56726/IRJMETS45714