Paper Key : IRJ************945
Author: Julekha Munaf Tade,Shreya Jangave ,Aqsa Kadri
Date Published: 09 Jul 2024
Abstract
In order to understand the interaction between the physical attributes of the nasal formulations and the spray patterns, it was studied if laser diffraction might be utilized to define the droplet-size distribution (DSD) of nasal sprays. With the use of Malvern Spraytec, the effects of actuation force (37 kg), rheological characteristics from carbopol 934PNF Avicel RC 591, and actuation distance on the aerosol DSD of nasal sprays were examined. By tracking the released nasal spray that contained a dye or a fluorescent marker, spray-pattern analysis was carried out. Minimum and maximum diameters, ovality, polydispersity, Dv10, Dv50, and Dv90 parameters were all included in the DSD and spray pattern parameters. Nasal-spray productsDv50 values were lowered by moving the actuation distance from 3 to 6 cm from the laser beam. The surface area and viscosity of Mometasone Furoate formulations using polymer as Avicel RC 591 formulations were found to have a power law connection through spray pattern analysis. In summary, a number of factors, including actuation force, viscosity, rheological characteristics, surface tension, and pump design, affect nasal aerosol generation character.Keywords: Droplet-size distribution (DSD), actuation, polydispersity , etc.