Paper Key : IRJ************682
Author: Dr Surya Haritha S,Habitha Sri
Date Published: 28 Oct 2023
Abstract
The ability to accurately forecast the effects of possible cancer chemotherapeutic medications in human systems using in vitro simulations is essential for their successful translation to the clinic. The necessity of improving efficient in vitro drug screening is driven by the high cost and extended duration of preclinical and clinical research. In many cases, 3D models are used instead of conventional cultures to simulate cell morphology and cell-interactions are applicable physiologically for forecasting treatment results for complicated varying malignancies. The development of tissue mimetic models and complex simulations of physiology are made possible by bio printing and microfluidic technology, respectively, providing more accurate prediction of drug interactions. Realistic tissue models are specifically organotypic tissue structures built using organ-on-a-chip or cell-laden matrices. The advancement in the screening of in vitro cancer medication led by bio printing and microfluidic chips, as well as associated difficulties, are highlighted in this review's projection of the progress made toward the development of biomimetic tissue models.