Paper Key : IRJ************062
Author: Bheemappa Teli
Date Published: 09 Jul 2024
Abstract
Gastroretentive drug delivery systems (GRDDS) are a novel and emerging area of pharmaceutical research that aims at enhancing oral medication administration through boosting drug residence time in the stomach. This review addresses the various GRDDS, including floating, mucoadhesive, swelling, high-density, and magnetic systems. Each system's mechanism, design concepts, and therapeutic applications are clarified in detail. The advantages of GRDDS, such as increased bioavailability, reduced dose frequency, and localized treatment of stomach problems, are balanced against the disadvantages, which include heterogeneity in gastric physiology and formulation complexity. The review also discusses current advances and future prospects in GRDDS, with a focus on breakthroughs such smart polymers, nanotechnology, and biomimetic techniques. This comprehensive study aims to highlight the potential of GRDDS to considerably improve therapeutic results for medications with narrow absorption windows or those that require targeted gastric distribution.