Paper Key : IRJ************733
Author: Anand Singh Chouhan,Priyanka Gupta
Date Published: 13 Jul 2024
Abstract
Type 2 diabetes mellitus (T2DM) is a well-established risk factor for cognitive decline and dementia, including Alzheimer's disease (AD) and vascular dementia. Despite extensive research and numerous publications, the precise mechanisms underlying these associations remain unclear. This review explores the current understanding of the links between T2DM and cognitive impairments, focusing on molecular and cellular features common to T2DM, type 1 diabetes mellitus (T1DM), and insulin resistance, all of which are associated with memory deficits and cognitive decline. Given these similarities, some researchers have proposed the term type 3 diabetes to describe Alzheimer's disease. This review aims to provide a comprehensive overview of the evidence supporting this hypothesis, highlighting potential pathways and mechanisms that contribute to the increased risk of dementia in individuals with diabetes. Understanding these connections is crucial for developing targeted therapeutic strategies to mitigate cognitive decline in diabetic patients.
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