Paper Key : IRJ************318
Author: Abhijit Ramnath Kadam,Onkar Prakash Deshmukh,Priyanka Machhindra Sagar
Date Published: 17 Oct 2023
Abstract
ABSTRACT The goal of this study was to create a transdermal treatment system of the matrix type. Using a solvent evaporation approach, the medication Aceclofenac is included in various ratios of hydrophilic (hydroxyl propyl cellulose) and hydrophobic (ethyl cellulose) polymeric systems. A plasticizer, 15% ww dibutyl phthalate, is added to the polymer weight. Aceclofenac's transdermal penetration was increased by varying the amounts of isopropyl myristate and oleic acid. There was no evidence of any incompatibility between the medicine and the polymers based on their physicochemical compatibility, which was examined using differential scanning calorimetry and infrared spectroscopy. The transdermal films that were prepared were examined physically in terms of their thickness, weight fluctuation, drug content, flatness, tensile strength, folding durability, moisture content%, and rate of water vapour transmission. Good physical stability was indicated by all the formulations produced.Human societies have been applying substances to the skin as cosmetic and medical agents for thousands of years. However, the use of the skin as a medicine delivery system did not begin until the 20th century. The term "transdermal" is actually dated by Merriam-Webster to 1944, indicating that it is a relatively new idea in pharmaceutical and medical practice. Transdermal medications come in a discreet, self-contained dose form. medication distribution via the skin to provide a systemic effect without causing variations in the drug's plasma concentration. The topical distribution of therapeutic agents presents numerous benefits in comparison to traditional oral and invasive drug delivery techniques.