Paper Key : IRJ************256
Author: Sanket Kalyan Walke ,Ms. Vaishnavi Chopade
Date Published: 20 Nov 2024
Abstract
ABSTRACT :Since the quick release and repeated dosing of the drug in traditional drug delivery systems may increase the danger of dose variation, a formulation with regulated release that maintains a nearly constant or uniform blood level is required. For medications that have short half-lives and need to be taken repeatedly, sustained release systems are thought to be a better option because they are simple to make and do not depend on the gastrointestinal tracts absorption process following oral administration. The fundamental goal of these dosage forms is to maximize drug delivery in order to attain a measure of therapeutic effect control in the face of unpredictable fluctuations in the in vivo environment where drug release occurs. Any medication delivery method that distributes the drug gradually over a long period of time is considered a sustained release system. Because sustained release keeps the therapeutic concentration of the medicine from changing in the body, it also offers a promising means of reducing the drugs negative effects. In order to increase usefulness, minimize side effects, and treat the disease, the sustained drug delivery systems underlying logic optimizes the drugs biopharmaceutical, pharmacokinetic, and pharmacodynamic properties. Improvements in drug therapy as determined by the balance between the benefits and drawbacks of using sustained release systems are the main objective of sustained release forms.Keywords: Sustained release, Dose Frequency, physicochemical properties of drugs, Biological Half life.