Paper Key : IRJ************129
Author: Pranay Kisan Khilare ,Ms.ulka Mote
Date Published: 20 Nov 2024
Abstract
Hydrogels, three-dimensional networks of hydrophilic polymers, are pivotal in advancing controlled drug delivery systems due to their remarkable ability to absorb water and biological fluids while maintaining structural integrity. These systems enable precise control over drug release rates, improving therapeutic efficacy and patient compliance. Modern hydrogels are tailored for stimuli-responsive drug release, reacting to environmental triggers such as pH, temperature, or enzymes, ensuring targeted delivery and reducing systemic toxicity. Significant advancements include injectable hydrogels for minimally invasive administration and nano-hydrogels that enhance drug loading and release efficiency. Biopolymers like chitosan and alginate, alongside synthetic polymers such as polyethylene glycol, are commonly used to design these systems. Innovations in hydrogel synthesis, such as crosslinking techniques, have improved their mechanical strength, biocompatibility, and degradability, making them suitable for personalized medicine applications.Hydrogel-based delivery systems offer benefits like sustained release, targeted delivery, and reduced dosing frequency, minimizing side effects and improving patient outcomes. Emerging research focuses on multi-drug delivery systems and combination therapies, integrating multiple functionalities into a single platform. Challenges remain in optimizing hydrogel properties and scaling production for clinical applications, but the potential of these systems in enhancing drug efficacy and patient care is undeniable.