Paper Key : IRJ************129
Author: Onkar B Doke,Prachi K Shitkal,Sanjana V Shinde,Sanika J Sonawane
Date Published: 21 Nov 2024
Abstract
Abstract:Transdermal drug delivery systems (TDDS) have evolved significantly since their early applications in the 1900s, offering an innovative alternative to traditional oral administration. This review discusses the history and development of transdermal patches, including their advantages such as avoidance of first-pass metabolism and prolonged drug action. Various types of transdermal patches are examined, including single-layer and multilayer drug-in-adhesive patches, vapor patches, and membrane-moderated reservoir patches, each designed to facilitate the effective and controlled release of medications. Key components such as backing layers, drug reservoirs, matrix membranes, and adhesives are detailed, alongside their role in the overall efficacy of the patches. The review also addresses the characterization and evaluation methods critical for ensuring the quality and performance of transdermal patches. Current FDA-approved formulations, such as those for fentanyl, nitroglycerin, and nicotine, are listed, highlighting their clinical applications. Finally, the advantages and disadvantages of TDDS are analyzed, underscoring their potential in modern therapeutic approaches while also noting challenges in drug formulation and skin compatibility.Keywords: Transdermal drug delivery systems, transdermal patches, adhesives etc.