Paper Key : IRJ************420
Author: Mr. Vivek H. Kavitake,Mr. Rajendra G. Kharade,Miss. Ashwini S. Kasved
Date Published: 15 Nov 2024
Abstract
Withania coagulans, also known as Indian Rennet or Paneer Doda, is a significant medicinal plant from the Solanaceae family, valued for its extensive therapeutic applications in traditional medicine. This review explores the phytochemical composition, pharmacological activities, and medicinal potential of W. coagulans, focusing on its role in managing diabetes and related metabolic disorders. The plant is rich in bioactive compounds, including withanolides, flavonoids, saponins, and phenolic compounds, which contribute to its antioxidant, anti-inflammatory, antihyperglycemic, and hepatoprotective properties. Research indicates that W. coagulans effectively reduces blood glucose levels, improves insulin sensitivity, and normalizes lipid profiles in diabetic models. Its compounds, such as withanolide J and coagulin E, have shown significant inhibitory effects on key enzymes involved in glucose metabolism. Furthermore, the plant exhibits wound healing, cardiovascular protective, and diuretic activities, making it a versatile therapeutic agent. Its traditional applications range from treating gastrointestinal disorders and toothaches to being used as a blood purifier. However, habitat loss and overexploitation have endangered its natural populations, emphasizing the need for conservation and sustainable use. Future studies should focus on elucidating its mechanisms of action, optimizing its bioavailability, and validating its therapeutic efficacy in clinical settings. W. coagulans represents a cost-effective, natural alternative to synthetic drugs, with minimal side effects and broad medicinal potential. This review underscores the significance of W. coagulans as a promising candidate for integrative and modern medical practices, particularly in the management of diabetes and associated health conditions