Paper Key : IRJ************955
Author: Kolhe Sakshi Narayan ,Wakchaure Tanaya P
Date Published: 07 Nov 2024
Abstract
Chrono pharmacology is an emerging field that studies the effects of biological rhythms on pharmacological responses. It examines how the timing of drug administration influences efficacy and toxicity, leveraging the body's circadian rhythms, which govern various physiological processes. This discipline seeks to optimize drug therapy by aligning medication schedules with the body's natural cycles, thereby enhancing therapeutic outcomes and minimizing side effects. Research indicates that drug absorption, metabolism, and elimination can vary significantly throughout the day, underscoring the importance of time in treatment strategies. By integrating chronobiology with pharmacotherapy, chrono pharmacology offers the potential for personalized medicine, ultimately improving patient care and therapeutic efficacy in a wide range of medical conditions. Future studies aim to refine these principles, exploring the implications of genetic, environmental, and lifestyle factors on drug response in relation to circadian rhythms. Chrono pharmacology is an interdisciplinary field that investigates the interplay between biological rhythms and pharmacological effects, focusing on how the timing of drug administration can influence therapeutic outcomes. Biological processes in the body, such as drug absorption, distribution, metabolism, and excretion, exhibit circadian variations, which can significantly affect drug efficacy and toxicity. By considering these rhythmic patterns, chrono pharmacology aims to optimize drug delivery schedules, enhancing therapeutic efficacy while reducing adverse effects. This field has implications across various therapeutic areas, including oncology, cardiology, and chronic pain management, where the timing of treatment can be crucial for maximizing benefits. For example, certain cancer therapies may be more effective when administered at specific times, aligning with tumour biology and patient circadian rhythms. Additionally, individual differencessuch as genetics, age, and lifestylefurther complicate pharmacological responses, highlighting the need for personalized approaches in drug therapy.Keywords: Chrono pharmacology, Circadian rhythms, Drug timing, Pharmacokinetics, Therapeutic efficacy, Adverse effects, Personalized medicine, biological rhythms, etc.