Paper Key : IRJ************362
Author: Gottam Manisha
Date Published: 10 Nov 2024
Abstract
Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred as peptic ulcers. It affects nearly 10% of world population. The present study was to investigate the antiulcer activity of methanolic extract of Canscora decussata (MECD) on albino Wistar rats. The present study was carried by pylorus ligation ulcer models in albino Wistar rats. The antiulcer activity of MECD (100 and 200) was compared with standard drugs (Ranitidine). In pyloric ligation induced ulcer model, the studied parameters were gastric volume, pH, total acidity, free acidity, and ulcer index was determined for severity of ulcers. In pyloric ligation model the volume of gastric content, totalfree acidity and pepsin activity was significantly decreased at p<0.05 and p<0.01 and pH of the gastric juice was significantly increased at p<0.05 and p<0.01 in MECD treated groups as compared to control group. All the doses of MECD showed dose dependent antiulcer effect as well as significant (p<0.05 and p<0.01) reduction in the ulcer index as compared to control group in all the experimental models. The results of the study indicate that the MECD have better potential against ulcer which supports the traditional claims in folklore medicine.
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