Paper Key : IRJ************337
Author: Dhumal Vaibhav Pandurang ,Ms Vaishnavi Chopade
Date Published: 15 Nov 2024
Abstract
Among newly discovered chemical entities, around 40% of drugs are lipophilic and struggle to reach the market due to poor aqueous solubility. For orally administered drugs, solubility is a key factor affecting their ability to reach desired concentrations in systemic circulation for effective pharmacological response. Solubility issues present a significant challenge for formulation scientists, who use various technological approaches during pharmaceutical product development to address this problem. Traditional techniques such as solid dispersion, micronization, and salt formation are commonly employed to improve the solubility of poorly soluble drugs, each with its own set of limitations and advantages. Emerging methods like nano-suspension, supercritical processing, and cryogenic technology offer promising opportunities for enhancing the delivery of poorly soluble drugs. Solubility remains a critical and challenging aspect of formulation development. This review focuses on both traditional and novel techniques for improving drug solubility to reduce the number of poorly soluble drug candidates that are discarded during development.