Paper Key : IRJ************667
Author: Amit Singh,Mr.pramod Mishra,Mr.sujeet Pratap Singh ,Mt.tarkeshwar Prasad Shukla
Date Published: 15 Nov 2024
Abstract
Curcumin, which is the major bioactive compound found in Curcuma longa (turmeric), has drawn a lot of interest owing to its numerous health benefits, especially in the fields of disease prevention and health promotion. This review goes into detail on understanding the molecular mechanisms of curcumins biological activities, especially its anti-inflammatory, antioxidant, anticancer, and neuroprotective properties. Curcumin is known to affect major cellular signaling pathways like NF-B, MAPK, and PI3KAkt to down-regulate inflammation and oxidative stress, which are critical for the development of many chronic diseases. Furthermore, curcumins role in cancer, cardiovascular diseases, diabetes, Alzheimers disease, arthritis management or mitigation, as well as immune enhancement has also been assessed. Nonetheless, the clinical use of curcumin is often compromised by its inadequate bioavailability leading to the development of novel drug delivery systems and bioenhancers. In spite of these setbacks, curcumin, because of its non-specificity, low toxicity and various biological effects, presents good possibilities for use in the development of new therapeutic regimens. In this review, we also address the recent trends in curcumin formulations such as: modern approaches towards improving curcumin therapy like nanomedicine and nanocarrier encapsulation. Most of the results gathered from preclinical studies show positive outcomes; however, it is necessary to conduct more clinical trials on curcumin to provide clear therapeutic indications. The review emphasizes the potential use of curcumin in the form of a phytochemical, as it imparts positive health effects and helps in preventing diseases.
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