Paper Key : IRJ************152
Author: Sangale Saurabh Bapu ,Deokate Aditya Abaso,Deokate Sanika Chandrakant ,Meera Deokar
Date Published: 16 Nov 2024
Abstract
Ocular drug delivery is challenged by the eye's complex anatomy and physiological barriers, which impede effective treatment for prevalent disorders such as cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy. Conventional delivery methods, including eye drops and injections, often result in low bioavailability and rapid drug clearance. This review examines the barriers to ocular drug delivery, categorizing them into precorneal, corneal, and blood-ocular barriers, while also exploring various dosage formsliquid, semisolid, solid, and mixedthat aim to enhance retention and reduce side effects. Notably, nanotechnology presents innovative solutions through nanocarriers, such as liposomes, niosomes, and polymeric nanoparticles, which improve drug penetration, stability, and targeted delivery. Key factors for effective application, including pH, stability, size, and zeta potential, are discussed. The review underscores the potential of nanostructured platforms to enhance therapeutic o